Two sample MR report
SRSF2_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | -0.6524501 | 0.8973367 | 0.5197692 |
| Weighted median | 5 | -0.1630710 | 0.0581261 | 0.0050243 |
| Inverse variance weighted | 5 | -0.1900356 | 0.0507589 | 0.0001812 |
| Simple mode | 5 | -0.2592266 | 0.0980813 | 0.0574014 |
| Weighted mode | 5 | -0.0956330 | 0.0933081 | 0.3633364 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 6.211768 | 3 | 0.1017497 |
| Inverse variance weighted | 6.763784 | 4 | 0.1489103 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.1673046 | 0.3240257 | 0.6412703 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 8.45e-05 | 0 | TRUE | 0.3919277 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
